大阪バイオサイエンス研究所・古川貴久(2006)。129背景。 Obif (osteoblast induction factor) 遺伝子のノックアウトマウス。Obifは、骨芽細胞特異的に発現する遺伝子である。ホモノックアウトマウスでは、14日齢および8週齢において、コントロール群よりも有意に骨量の減少が認められている。 Furukawa Takahisa 条件を付加する。<br>研究成果の公表にあたって寄託者の指定する文献を引用する。Dev. Growth Differ., 54(4):474-480 (2012).<br>利用者は、事前に寄託者の提供承諾(大阪大学とのMTA締結)を得る。 mouse phosphoglycerate kinase promoter (PGK promoter), E. coli neo, SV40 Poly A signal, mouse Tmem119 genomic DNA <a href='https://brc.riken.jp/mus/pcr05501'>Genotyping protocol -PCR-</a> C (3-6 months) C(3〜6か月) Developed by Takahisa Furukawa, Osaka Bioscience Institute in 2006. 129 background. Homozygote x Heterozygote [or Crossing to 129S6/SvEvTac] Homozygote x Heterozygote [or Crossing to 129S6/SvEvTac] TC1 [129S6/SvEvTac] In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Dev. Growth Differ., 54(4):474-480 (2012).Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must contract an MTA with the DEPOSITOR (Osaka University). 129-Tmem119<tm1Tfur> 129-Tmem119<tm1Tfur> true 古川 貴久 RBRC05501 129-Obif KO, 129-Obif<tm1Tfur> 129-Obif KO, 129-Obif<tm1Tfur> Necessary documents for ordering:<ol><li>Order form (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_4.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_b.docx">English</A>)</li><li>Category I MTA: MTA for distribution with RIKEN BRC (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_5.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_c.docx">English</A>)</li><li>Acceptance of responsibility for living modified organism (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_7.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_g.docx">English</A>)</li></ol> Obif, osteoblast induction factor gene knockout mice. Exon 2 of Obif gene was replaced with PGK-neo cassette. Homozygous mutant mice show lower bone mass than controls at 14 days and 8 weeks old.